thrombin inhibitor 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10081	Thrombin inhibitor 1		Thrombin
	Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).		Thrombin
T7625	TRAP-6	PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)	Protease-activated Receptor
	TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).		Protease-activated Receptor
T1986L	Atopaxar Hydrobromide		Protease-activated Receptor
	Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.		Protease-activated Receptor
T1986	Atopaxar	E5555,ER-172594-00	Protease-activated Receptor
	Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.		Protease-activated Receptor
T5519	Bivalirudin	BG-8967,Hirulog-1	Thrombin
	Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.		Thrombin
T8917	PAR-2-IN-1	IUN76750	Protease-activated Receptor
	PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.		Protease-activated Receptor
T10951	Dabigatran ethyl ester hydrochloride		Others , Thrombin
	Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.		Others , Thrombin
T9845	Thrombin inhibitor 5
	Thrombin inhibitor 5 (compound 385) is a thrombin inhibitor with IC 50s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for venous thromboembolism research[1].
T9892	JAMM protein inhibitor 2	Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-	Others
	JAMM protein inhibitor 2 (Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-) is an inhibitor of JAMM protease and can be used for anticancer studies. The IC50s are 10 μM, 46 μM, and 89 μM for thrombin,...		Others
T1893	Parmodulin 2	ML 161	Protease-activated Receptor
	Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thromb...		Protease-activated Receptor
T2368L	Edoxaban	Lixiana	Factor Xa , Thrombin
	Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is a...		Factor Xa , Thrombin
T72448	Thrombin inhibitor 6
	Thrombin Inhibitor 6, with an IC 50 of 1 nM, acts as a potent anticoagulant by inhibiting thrombin.
T80097	Hirullin P18		Thrombin
	Hirullin P18 is a potent thrombin inhibitor with anticoagulant properties [1].		Thrombin
T77221	Benzenecarboximidamide, hydrochloride, hydrate (1:1:x)
	Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with K i s of 20, 21, 97, 110, 320 and 750 μM against Tryptas...
T36777	Thrombin Receptor Agonist Peptide (trifluoroacetate salt)
	Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor. It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma. TRAP-14 (100 μM) ...
T11100	DS-1040 Tosylate		Others
	DS-1040 Tosylate is an oral active, selective thrombolytic inhibitor with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa, is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhi...		Others
T73751	Lepirudin
	Lepirudin, a recombinant form of hirudin, serves as a potent, irreversible inhibitor of thrombin, showcasing its anticoagulant efficacy in heparin-induced thrombocytopenia (HIT) [1].
T80738	Z-FK-ck	Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone
	Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) serves as a potent, selective inhibitor of gingipain-K. This compound effectively extends plasma thrombin time (TT) proportionally with dosage and duration [1].
T75242	Bivalirudin TFA
	Bivalirudin TFA, a synthetic 20-residue peptide, serves as a reversible inhibitor of thrombin. Its IC50 value highlights its target specificity in vitro, where, combined with Eptifibatide (8 mg/mL) at a low concentration...
T82286	Glycylglycylcysteine
	Glycylglycylcysteine is an inhibitor of Thrombin Activatable Fibrinolysis Inhibitor (TAFI), exhibiting a K_i value of 0.99 µM and an IC_50 of 9.4 µM in TAFI substrate assays. TAFI, a basic carboxypeptidase, hinders fibri...